Table 2. Functional annotation of the top biomarker candidates.
| Functional cluster | GO_ID | Count | % | p-Value | Genes |
|---|---|---|---|---|---|
| Protein localization | GO:0008104 | 14 | 0.867 | 0.0139 | GDI1, CLTA, NFKBIE, CHMP5, NAPA, MYH9, RAB11FIP4, CDC42, STX18, KIFAP3, CD81, RAB11B, GNAS, GOSR2 |
| Macromolecular complex subunit organization | GO:0043933 | 13 | 0.805 | 0.0065 | WASF1, FADD, EVL, EIF2A, CDK7, SF3B3, SDHAF1, MAZ, KIFAP3, SNRNP200, STMN1, TUBA1A, SPAST |
| Structural molecule activity | GO:0005198 | 12 | 0.743 | 0.0060 | RPL35A, NUMA1, CLTA, CLDN9, RPS16, MYL6B, MRPS24, LMNA, RPL27, TUBA1A, RPL21P16, RPL36AL |
| Intracellular transport | GO:0046907 | 12 | 0.743 | 0.0098 | CLTA, KIF5B, STX18, MYL6B, CHMP5, SLC25A6, GOSR2, GNAS, NAPA, MYH9, FTH1, SPAST |
| Cytoskeletal protein binding | GO:0008092 | 11 | 0.682 | 0.0035 | NUMA1, TWF2, KIF5B, WASF1, KIFAP3, EVL, STMN1, MYH9, COTL1, SPAST, FARP2 |
| Macromolecular complex assembly | GO:0065003 | 11 | 0.682 | 0.0266 | MAZ, WASF1, KIFAP3, SNRNP200, EIF2A, FADD, CDK7, TUBA1A, SDHAF1, SF3B3, SPAST |
| Microtubule-based process | GO:0007017 | 9 | 0.558 | 0.0006 | KIF5B, KIFAP3, KIF18B, STMN1, MYH9, DYNC1H1, TUBA1A, SPAST, DCTN2 |
| Cell proliferation | GO:0008283 | 9 | 0.558 | 0.0162 | PRPF19, LRP1, CD81, ZNF259, CDK7, CSRP2, FTH1, LRPAP1, DCTN2 |
| Cytoskelet onorganization | GO:0007010 | 9 | 0.558 | 0.0162 | CDC42, NISCH, WASF1, EVL, STMN1, MYH9, DYNC1H1, SPAST, DCTN2 |
| Protein complex assembly | GO:0070271 | 9 | 0.558 | 0.0350 | MAZ, WASF1, KIFAP3, FADD, CDK7, TUBA1A, SDHAF1, SF3B3, SPAST |
%,.number of genes associated with functional cluster/total number of query genes