Table 2. Hemagglutination inhibition titers of H7 Monoclonal Antibodies (mAbs).
Virus | Hemagglutination Inhibition Titers (μg/ml)a | |||
---|---|---|---|---|
5A6* | 4A2* | 2C4* | H9-A22** | |
A/Shanghai/02/2013 | 12.5 | 12.5 | 12.5 | >100 |
A/Shanghai/02/2013 A143T | >100 | >100 | >100 | >100 |
A/Shanghai/02/2013 S183D | 6.25 | 6.25 | 6.25 | >100 |
A/Shanghai/02/2013 V195G | 6.25 | 6.25 | 6.25 | >100 |
A/Shanghai/02/2013 A198T | 12.5 | 12.5 | 12.5 | >100 |
A/Netherlands/219/2003 | >100 | >100 | >100 | >100 |
A/Netherlands/219/2003 T143A | 6.25 | 12.5 | 6.25 | >100 |
A/Netherlands/219/2003 D183S | >100 | >100 | >100 | >100 |
A/Netherlands/219/2003 G195V | >100 | >100 | >100 | >100 |
A/Netherlands/219/2003 T198V | >100 | >100 | >100 | >100 |
A/Puerto Rico/8/1934 | >100 | >100 | >100 | 3.13 |
a Lowest antibody concentration that inhibited H7 virus-mediated hemagglutination of turkey red blood cells; initial mAb concentration 100 μg/ml.
* mAbs 5A6, 4A2, and 2C4 to site A were raised against HA of A/Shanghai/02/2013.
** mAb were raised against A/Puerto Rico/8/1934.