Table 2.

Correlations between SPOCK1 Expression and other important clinicopathological parameters in urothelial carcinomas.

Parameter	Category	Upper Urinary Tract Urothelial Carcinoma				Urinary Bladder Urothelial Carcinoma
		Case No.	SPOCK1 Expression		P value	Case No.	SPOCK1 Expression		P value
			Low	High			Low	High
Gender&	Male	158	82	76	0.514	216	105	111	0.489
	Female	182	88	94		79	42	37
Age (years)#		340	65.16±10.91	66.00±8.76	0.961	295	65.27±13.02	66.81±11.35	0.543
Tumor location&	Renal pelvis	141	66	75	0.194	-	-	-	-
	Ureter	150	83	67		-	-	-	-
	Renal pelvis & ureter	49	21	28		-	-	-	-
Multifocality&	Single	278	143	135	0.261	-	-	-	-
	Multifocal	62	27	35		-	-	-	-
Primary tumor (T) &	Ta	89	61	28	<0.001*	84	70	14	<0.001*
	T1	92	57	35		88	42	46
	T2-T4	159	52	107		123	35	88
Nodal metastasis&	Negative (N0)	312	163	149	0.006*	266	138	128	0.033*
	Positive (N1-N2)	28	7	21		29	9	20
Histological grade &	Low grade	56	41	15	<0.001*	56	46	10	<0.001*
	High grade	284	129	155		239	101	138
Vascular invasion&	Absent	234	148	86	<0.001*	246	140	106	<0.001*
	Present	106	22	84		49	7	42
Perineural invasion&	Absent	321	169	152	<0.001*	275	144	131	0.001*
	Present	19	1	18		20	3	17
Mitotic rate (per 10 high power fields)#		340	10.63±12.07	13.99±12.30	<0.001*	295	12.41±13.89	16.39±13.95	0.001*

&, Chi-Square test; #, Mann-Whitney U test; * Statistically significant.