Table 1.
Maternal characteristics, medication use, and immediate birth outcomes of 41,173 included pregnancies
| History of triptan use | No triptan history | |||
|---|---|---|---|---|
| During pregnancy N=396 | Pre-pregnancy Only N=798 | Migraine N=3,291 | N=36,688 | |
| Age in years (Mean, SD) | 30.8(4.4) | 30.5(4.5) | 30.3(4.5) | 30.4(4.4) |
| BMI (kg/m2) | ||||
| <18.5 | 2.81 | 2.4 | 3.7 | 2.6 |
| 18.5–25 | 59.6 | 59.9 | 61.8 | 66.9 |
| >25 | 37.6 | 37.2 | 34.5 | 30.5 |
| Multiparous | 49.2 | 45.9 | 53.5 | 53.4 |
| Married or cohabitating | 95.5 | 98.0 | 97.0 | 97.6 |
| Mother Education | ||||
| Primary or secondary | 31.1 | 31.8 | 37.0 | 31.0 |
| University or higher | 68.9 | 68.2 | 63.0 | 69.0 |
| Smoking during pregnancy | 11.4 | 11.7 | 13.1 | 11.1 |
| Alcohol during pregnancy | 20.5 | 15.0 | 15.0 | 17.1 |
| Folate Supplementation | 60.9 | 62.2 | 57.8 | 59.2 |
| Multivitamin Supplementation | 37.9 | 43.7 | 38.9 | 37.0 |
| Migraine Preventive Therapy | 1.8 | 1.8 | 0.6 | 0.0 |
| Opioids | ||||
| Pre-pregnancy | 8.1 | 5.3 | 5.1 | 1.3 |
| In pregnancy | 12.9 | 4.6 | 4.9 | 1.4 |
| Acetaminophen | ||||
| Pre-pregnancy | 46.5 | 47.9 | 44.8 | 25.4 |
| In pregnancy | 76.8 | 70.1 | 63.7 | 42.6 |
| NSAIDs | ||||
| Pre-pregnancy | 22.0 | 25.9 | 23.3 | 9.9 |
| In pregnancy | 22.5 | 11.2 | 12.6 | 5.9 |
| Anti-convulsants | ||||
| Pre-pregnancy | 0.5 | 0.5 | 0.2 | 0.1 |
| In pregnancy | 0.3 | 0.3 | 0.3 | 0.2 |
| Antidepressants | ||||
| Pre-pregnancy | 5.3 | 4.6 | 3.8 | 2.2 |
| In pregnancy | 2.0 | 1.1 | 1.6 | 0.9 |
| Benzodiazepines | ||||
| Pre-pregnancy | 1.8 | 1.4 | 0.9 | 0.5 |
| In pregnancy | 1.8 | 0.5 | 0.5 | 0.4 |
| Maternal depressive/anxiety symptoms1 (Mean, SD) | 0.2(1.7) | 0.0(1.8) | 0.2(1.9) | −0.2(1.6) |
| Pre-eclampsia | 7.8 | 4.3 | 4.0 | 3.5 |
| Small for Gestational Age | 6.6 | 6.3 | 6.5 | 6.2 |
| Apgar 5 (<7) | 1.5 | 1.0 | 0.7 | 0.9 |
| Preterm | 4.0 | 4.6 | 4.8 | 4.6 |
| Low Birth Weight | 2.0 | 2.3 | 2.6 | 2.4 |
| Externalizing Problems (z ≥ 1.5) | 11.6 | 8.3 | 9.1 | 7.7 |
| Internalizing Problems (z ≥ 1.5) | 6.8 | 8.6 | 7.7 | 6.2 |
1
Figures shown are percent of column total with the exception of maternal age and depressive/anxiety symptom severity, presented as mean(standard deviation)