Table 4.
Comparison of risk of clinically-significant internalizing behavior problems for exposure to triptans
| Among all mothers (n=41,173)
| ||||||
|---|---|---|---|---|---|---|
| Total N | N with outcome | Crude Risk Ratio (95% Confidence Interval) | Adjusted Risk Ratio1 (95% Confidence Interval) | Crude Risk Difference (95% Confidence Interval) | Adjusted Risk Difference1 (95% Confidence Interval) | |
| Triptans in pregnancy | 396 | 27 | 0.79 [0.51, 1.21) | 0.78 [0.51, 1.19] | −0.02 [−0.05, 0.01] | −0.02 [−0.05, 0.01] |
| Vs.Triptans pre-pregnancy only | 798 | 69 | Referent | Referent | Referent | Referent |
| Triptans in pregnancy | 396 | 27 | 0.88 [0.60, 1.29) | 0.89 [0.61, 1.30] | −0.01 [−0.04, 0.02] | −0.01 [−0.03, 0.01] |
| Vs. Migraine with no triptan use | 3,291 | 255 | Referent | Referent | Referent | Referent |
| Triptans in pregnancy | 396 | 27 | 1.09 [0.78, 1.58) | 1.02 [0.71, 1.47] | 0.01 [−0.02, 0.03] | 0.00 [−0.03, 0.02] |
| Vs. Population (no triptan use or migraine) | 36,688 | 2284 | Referent | Referent | Referent | Referent |
|
| ||||||
| Among mothers with migraine (n=4,439) | ||||||
|
| ||||||
| Total N | N with outcome | Crude Risk Ratio (95% Confidence Interval) | Marginal Structural Model Risk Ratio2 (95% Confidence Interval) | Crude Risk Difference (95% Confidence Interval) | Marginal Structural Model Risk Difference2 (95% Confidence Interval) | |
|
| ||||||
| Pre- pregnancy triptan use | 1,085 | 86 | 1.32 [1.04, 1.66] | 1.04 [0.80, 1.35] | 0.02 [0.00, 0.04] | 0.00 [−0.02, 0.03] |
| Vs.no pre-pregnancy | 3,354 | 260 | Referent | Referent | Referent | Referent |
| Triptans in 1st trimester | 304 | 20 | 0.90 [0.54, 1.48] | 1.27 [0.57, 2.82] | −0.01 [−0.04, 0.03] | 0.02 [−0.06, 0.10] |
| Vs. No triptan use in 1st trimester | 4,135 | 326 | Referent | Referent | Referent | Referent |
| Triptans in 2nd /3rd trimester | 137 | 7 | 0.69 [0.32, 1.50] | 0.70 [0.16, 3.14] | −0.02 [−0.07, 0.02] | −0.02 [−0.11, 0.07] |
| Vs. No triptan use in 2nd/3rd trimester | 4,302 | 339 | Referent | Referent | Referent | Referent |
1
Models adjusted for maternal age, pre-pregnancy BMI, parity, marital status, education, cigarette and alcohol use, comedication use (NSAIDs, acetaminophen, opioids, antidepressants), depressive and anxiety symptoms.
2
Marginal structural models weighted with stabilized inverse probability of treatment weights, constructed at each time point using baseline confounders, time-invariant confounders, and medication history.