Figure 5. Adipo-PTHR-KO mice are resistant to 5/6 nephrectomy-driven cachexia.

(A-F) Mice underwent sham or 5/6 nephrectomy (5/6 Nx) surgery and were sacrificed 5 weeks later (n = 5-6). Blood Urea Nitrogen (BUN) (A) and plasma PTH (B) levels were measured. Mice were placed into metabolic cages between post-surgery weeks 2 and 3, when the difference in body weight was small. Oxygen consumption (VO₂) (C), physical activity (D) and body weight (E) were monitored. Fat and muscle tissues were dissected and weighed (F). The values are mean ± SEM. (*) refers to differences between the Sham and 5/6 Nx groups. (#) refers to differences between the WT-5/6 Nx and KO-5/6 Nx groups. *P < 0.05, **P < 0.005, ***P < 0.0005, #P < 0.05, ##P < 0.005. See also Figure S4.