TABLE 4.

Nicotine pharmacokinetic profiles from various electronic cigarettes

Subject	Half-life (min)	Tmax (min)	Cmax (ng/mL)	AUC(0→∞) (ng/mL•min)	Delivered nicotine dose (mg)	Retained nicotine dose (mg)	PK-estimated nicotine dose (mg)
1	148	2	6.9	815	0.84	0.84	0.98
2	81	5	9.1	1345	1.64	1.63	1.61
3	87	30	2.3	301	1.66	0.82	0.36
4	152	5	8.9	1570	2.64	2.34	1.88
5	62	2	15.5	682	1.33	1.30	0.82
6	94	2	3.1	264	n/a	n/a	0.32
7	152	2	19.8	1813	2.43	2.42	2.18
8	132	5	8.7	1336	1.63	1.52	1.60
9	140	5	4.4	461	0.58	0.58	0.55
10	78	2	6.1	332	0.60	0.60	0.40
11	114	2	13.2	900	1.45	1.44	1.08
12	107	2	4.7	411	0.42	0.42	0.49
13	36	2	6.8	721	0.70	0.69	0.87
Average	106.3	5.1	8.4	843	1.33	1.22	1.01
Median	107	2	5.1	721	1.39	1.07	0.87
SD	37.2	7.6	5.1	519	0.73	0.68	0.62
LCI	84	0.5	5.4	529	0.87	0.80	0.63
UCI	129	9.7	11.5	1156	1.79	1.66	1.39

Notes: SD, standard deviation; LCI and UCI, lower and upper limits of 95% confidence interval; PK-estimated nicotine dose is average population clearance of nicotine (~1200 mL/min) × AUC_(0–∞)