Figure 2. The abnormal expression of 5-HT2B and 5-HT2C receptors in the brainstem of DBA/2 mice.
Compared with seizure-resistant C57BL/6J mice, the expression of 5-HT2B receptors was elevated, and that of 5-HT2C receptors was reduced in the caudal brainstem of DBA/2 mice. These results may partly explain the differential effect of mCPP, a 5-HT2B/2C receptor agonist, on the incidence of S-IRA in DBA/1 and DBA/2 mice. The error bars represent SDs.
* Significantly different from C57BL/6J mice at p < 0.05. From [42] with permission.