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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Epilepsy Behav. 2015 Aug 10;71(Pt B):174–180. doi: 10.1016/j.yebeh.2015.06.008

Figure 3. Fluoxetine did not increase basal breathing and ventilatory response to CO2 in anesthetized and conscious DBA/1 mice.

Figure 3

A, representative traces of minute ventilation (VE), respiratory frequency (fR) and tidal volume (VT) from anesthetized DBA/1 mice treated with fluoxetine (30 mg/kg) or vehicle, in room air or exposure to air + 7% CO2. Data were normalized to the average VE, fR or VT baseline value. Traces between the two dotted lines indicate the exposure time to 7% CO2 gas mixture. B, effects of fluoxetine on the normalized VE, fR and VT in room air and in air + 7% CO2 in anesthetized DBA/1 mice using nose-only plethysmography. C, effects of fluoxetine on the normalized VE, fR and VT in room air and in air + 7% CO2 in conscious DBA/1 mice using whole-body plethysmography. The error bars represent SEMs.

* p<0.05; ** p<0.01: significantly different from corresponding vehicle control. From [41] with permission.