STEPP of 5-year breast cancer-free interval (BCFI) in the HR+/HER2- population, according to level of Ki-67 expression, for each of the four cohorts defined by trial and chemotherapy use: (A) SOFT no chemotherapy; (B) TEXT no chemotherapy; (C) TEXT chemotherapy; (D) SOFT prior chemotherapy. P-values are from permutation tests of Ki-67-by- treatment interaction
Abbreviations: HR+=hormone receptor positive; OFS=ovarian function suppression; STEPP=subpopulation treatment effect pattern plot