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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Pharmacol Biochem Behav. 2015 Dec 15;142:1–7. doi: 10.1016/j.pbb.2015.12.004

Figure 2. Dextromethorphan-Pyrilamine Interactions (N=15, mean±sem).

Figure 2

A) Locomotor activity: The dextromethorphan main effect was significant The pyrilamine main effect was significant (p<0.0005), with both the 13.3 (p<0.005) and 40 mg/kg (p<0.005) pyrilamine doses significantly decreasing locomotor activity relative to control.

B) Food motivated responding: The dextromethorphan main effect was significant (p<0.0005), with the 30 mg/kg dose significantly decreasing (p<0.01) food self-administration relative to control. The main effect of pyrilamine was significant (p<0.0005), decrease food self-administration in a dose-related manner (n=11). Both the low and high doses (p<0.005) of pyrilamine resulted in a significant decrease in food self-administration relative to saline injection. The 13.3 mg/kg dose of pyrilamine significant reductive interactions with both the low (p<0.0005) and high dose of dextromethorphan, (p<0.0005) compared to saline injection (n=11). Treatment with the high dose of pyrilamine also had significant reductive interactions with both the low dose of dextromethorphan (p<0.0005) and the high dose of dextromethorphan, (p<0.0005) compared to saline injection.

C. Nicotine self-administration: The dextromethorphan main effect was significant. Pyrilamine had a significant (p<0.001), main effect (n=11). The 13.3 mg/kg pyrilamine dose significantly (p<0.0005) decreased nicotine self-administration relative to control.