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. 2016 Jan 28;6(1):84–93.

Figure 3.

Figure 3

Extracellular PrP deposits and intracellular tau aggregates shown by immunohistochemistry and Thioflavin S in the frontal cortex of the PRNP F198S carrier. 3F4 immunohistochemistry reveals unicentric and multicentric PrP immunopositive plaques (A, C). AT8 immunohistochemistry reveals tauimmunopositive neurons and neuropil threads (B, D). Plaques and neurofibrillary tangles are fluorescent with Thioflavin S. PrP deposits and tau aggregates are shown at two different magnifications (A, B = 50 × total magnification and C-E = 100 × total magnification).