Fig. 2.

Effect of uc.48+ siRNA on the mechanical withdrawal threshold or thermal withdrawal latency in DM rats. a The mechanical withdrawal threshold (MWT) was measured. The MWT in DM rats treated with uc.48+ siRNA was higher than that in DM rats (p < 0.001). There was no difference between the DM group and DM + scramble siRNA group (DM + negative control siRNA: DM + NC si group) (p > 0.05). The upper limit of mechanical withdrawal threshold (MWT) detection was 26.0 g. Mean ± SEM, n = 8. ***p < 0.001 compared to the control group; ^### p < 0.001 compared to the DM group. b The thermal withdrawal latency (TWL) was measured. The TWL in DM rats treated with uc.48+ siRNA was higher than that in DM rats (p < 0.001). There was no difference between the DM group and DM + scramble siRNA group (DM + NC si group) (p > 0.05). The upper limit of the thermal withdrawal latency detection was 30 s. Mean ± SEM, n = 8. ***p < 0.001 compared to the control group; ^### p < 0.01 compared to the DM group