Fig. 4.

a, b Effects of uc.48+ siRNA on the expression of TNF-α protein in the DRG of DM rats. Image analysis revealed that the levels (integrated optical density) of TNF-α protein (normalized to each β-actin internal control) in the DM group were higher than those in the control group. The levels of TNF-α protein in DM rats treated with uc.48+ siRNA were significantly lower than those in the DM group. There were no differences in TNF-α protein expression between the DRG from the DM group and DM + NC si group. Mean ± SEM, n = 8. **p < 0.01 compared to the control group; ^## p < 0.01 compared to the DM group