Fig. 3.

Differential B lymphocyte response to brain injury in A₁R^−/− mice 7 days after HI. S.C. sham contralateral hemisphere, S.I. sham ipsilateral hemisphere, HI.C. HI contralateral hemisphere, HI.I. HI ipsilateral hemisphere. a There was a robust B lymphocyte response in WT animals with increased percentage of live brain-infiltrating cells 1 week after HI. In A₁R^−/− mice, B lymphocytes failed to respond to the HI insult, although sham-operated animals had a significantly higher B lymphocyte infiltration than WT controls. b The number of CD86⁺ B lymphocytes increased after HI, however, only in the WT and not in the A₁R^−/−. c Antigen presenting function of B lymphocytes from A₁R^−/− mice appeared similar as the HI-induced change in MHC class II expression was comparable to WT (ANOVA p = 0.002 for treatment). Error bars indicate SE. A₁R^−/− sham-operated group n = 9, A₁R^−/− HI group n = 16, WT sham-operated group n = 6, WT HI group n = 3. *p < 0.05 and ***p < 0.001