Table 2.
Effect of SNC-Fc on human saphenous vein organ culture model.
Fc | SNC-Fc | |
---|---|---|
Intimal area/length of vein segment (μm) | 8.68 ± 1.85 | 1.28 ± 0.60⁎ |
% intimal cells BrdU positive | 30.4 ± 7.2 | 13.6 ± 3.6⁎ |
% medial cells BrdU positive | 11.6 ± 3.1 | 5.0 ± 1.3⁎ |
Medial density (cell/m2 × 1000) | 14.13 ± 3.3 | 15.44 ± 2.8 |
Migration into intima (non-BrdU cells/length × 1000) | 2.9 ± 2.0 | 2.5 ± 0.8 |
% intimal cells ISEL positive | 6.23 ± 1.6 | 3.06 ± 0.73⁎ |
% medial cells ISEL positive | 3.18 ± 0.60 | 1.95 ± 0.22⁎ |
Endothelial coverage (fold change from Fc) | 1 ± 0 | 2.92 ± 0.68⁎ |
% endothelial cells ISEL positive | 9.44 ± 1.58 | 3.49 ± 1.0⁎ |
Mean ± SEM.
Indicates a significant difference from the Fc control sample, paired Student's t-test, p < 0.05, n = 5.