Figure 8. Niche role of muscle in AMP reactivation.
Scheme illustrating the muscle niche-induced Insulin/Notch/dMyc cascade governing the reactivation of dormant AMPs. During embryonic stages, quiescent AMPs send out filopodia and make contact with neighboring muscles. These AMP-to-muscle ties persist until the AMPs are reactivated at mid-second larval instar, facilitating the reception of the inductive dIlp6 signal emitted by the muscle niche. In reactivated AMP (depicted in red), activation of the Insulin pathway leads to a Deltex-involving activation of Notch and induces AMP proliferation through the Notch target Myc.