Table 1.
Main characteristics of the female population by diabetic and cancer status
| Characteristics | Cases | p-vala1 | Controls | p-vala1 | p-valb2 | ||
|---|---|---|---|---|---|---|---|
| No DM (N = 835) | DM (N = 81) | No DM (N = 995) | DM (N = 99) | ||||
| Age | 62.0 (8.7) | 68.9 (8.0) | <0.01 | 64.1 (9.14) | 71.7 (8.4) | <0.01 | <0.01 |
| Study level | |||||||
| No studies | 168 (20.1) | 33 (40.7) | 192 (19.3) | 41 (41.4) | |||
| <High school | 319 (38.2) | 27 (33.3) | 357 (35.9) | 32 (32.3) | |||
| High school | 235 (28.1) | 15 (18.6) | 283 (28.4) | 16 (16.2) | |||
| >High school | 113 (13.5) | 6 (7.4) | <0.01 | 163 (16.4) | 10 (10.1) | <0.01 | 0.32 |
| BMI (kg/m2) | |||||||
| <25 | 316 (37.8) | 14 (17.3) | 462 (46.4) | 19 (19.2) | |||
| 25–30 | 338 (40.5) | 29 (35.8) | 339 (34.1) | 38 (38.4) | |||
| >30 | 181 (21.7) | 38 (46.9) | <0.01 | 194 (19.5) | 42 (42.4) | <0.01 | <0.01 |
| Age menarche | |||||||
| <12 years | 171 (20.5) | 13 (16.1) | 213 (21.4) | 23 (23.2) | |||
| 12–13 years | 378 (45.2) | 39 (48.1) | 445 (44.7) | 33 (33.4) | |||
| >13 years | 286 (34.3) | 29 (35.8) | 0.69 | 337 (33.9) | 43 (43.4) | 0.09 | 0.17 |
| Age first birth | 27.0 (26.3) | 27.0 (4.8) | 0.21 | 26.0 (26.4) | 27 (26.4) | 0.97 | 0.75 |
| Family history BC | |||||||
| No | 721 (86.4) | 72 (88.9) | 905 (91.0) | 83 (83.8) | |||
| Yes | 114 (13.7) | 9 (11.1) | 0.52 | 90 (9.1) | 16 (16.2) | 0.02 | <0.01 |
| Previous biopsies | |||||||
| No | 742 (88.9) | 76 (93.8) | 979 (98.4) | 98 (99.0) | |||
| Yes | 93 (11.1) | 5 (6.2) | 0.17 | 16 (1.6) | 1 (1.0) | 0.65 | <0.01 |
| Screening behavior (mammogram last 5 years) | |||||||
| No | 91 (8.8) | 17 (15.9) | |||||
| Yes | 949 (91.3) | 90 (84.1) | 0.02 | <0.01 | |||
| DM characteristics | |||||||
| Duration | – | 8.73 (7.9) | – | 8.6 (7.1) | 0.95 | ||
| Treatment | |||||||
| Conservative | – | 14 (17.3) | – | 21 (21.2) | |||
| Drugs | – | 67 (82.7) | – | 78 (78.8) | 0.51 | ||
| Tumor characteristics | |||||||
| Bilateral | |||||||
| Yes | 798 (97.6) | 79 (97.5) | – | – | |||
| No | 20 (2.4) | 2 (2.5) | 0.99 | – | – | – | |
| Histologic subtype | |||||||
| Ductal | 608 (85.0) | 64 (87.7) | – | – | |||
| Lobular | 53 (7.4) | 4 (5.5) | – | – | |||
| Other | 54 (7.6) | 5 (6.9) | 0.80 | – | – | – | |
| *Subtypes | |||||||
| RH+, HER2− | 529 (73.1) | 51 (66.2) | – | – | |||
| HER2+ | 121 (16.7) | 9 (11.7) | – | – | |||
| Triple− | 74 (10.2) | 17 (22.1) | 0.01 | – | – | – | |
Data are number of participants (percentage) for categorical variables or means (SD) for continuous variables
DM diabetes mellitus
ap-val1: p value from Chi-square or ANOVA test for differences in the distribution of the studied variables by diabetic status; b p-val2: p value from Chi-square or ANOVA test for differences in the distribution of the studied variables by case/control status
* Numbers in tables differ because not all tumors could be classified according to intrinsic subtypes