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Dafachronic acid plays important roles in developing and adult worms. Steroid signaling is important for entry into the Dauer diapause (A); longevity in response to germline ablation (B); and the response to dietary restriction (C). In contrast to (A,B), which are dependent on the activation of DAF-12, dietary restriction induces longevity via NHR-8. Adapted from Dumas et al. (31).
