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. 2016 Jan 28;2016:7678542. doi: 10.1155/2016/7678542

Figure 5.

Figure 5

Analysis of innate immune response after pneumococcal meningitis in different brain regions. 30 h after subarachnoid infection with Streptococcus pneumoniae, mRNA expression of TNF-α (a and e), IL-6 (b and f), IL-1β (c and g), and IL-1RA (d and h) was determined in the hippocampal formation and cortex of TNFR1-, IL-6-, or TNFR1-IL-6-KO and WT mice by real-time RT-PCR. Data were assessed from five independent experiments in duplicate. An asterisk indicates a significant difference between infected WT and infected TNFR1-, IL-6-, or TNFR1-IL-6-KO mice as determined by ANOVA followed by Bonferroni test (∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001).