Table 1.

Antimicrobial activity of synthesized platensimycin analogue.

Sl. number	Analogues name	Analogues structure	Antimicrobial activity	Reference
1	(−)-Platencin		Inhibits both FabF and FabH with similar potency	[12]
2	7-Phenylplatensimycin		MIC against S. aureus (MSSA), 0.25 μg/mL	[15]
3	11-Methyl-7-phenylplatensimycin		MIC against S. aureus (MSSA), <0.25 μg/mL	[15]
4	Sulfonamide analogues of platensimycin		Not tested	[16]
5	Oxazinidinyl platensimycin		MIC of 90 μg/mL against S. aureus, S. agalactiae, and B. subtilis	[17]
6	Isoplatencin		MIC against S. aureus (MSSA), 0.4 μg/mL	[18]
7	Cl-iso-platencin		MIC against S. aureus (MSSA), >25.6 μg/mL	[18]
8	Cl-platencin		MIC against S. aureus (MSSA), >25.6 μg/mL	[18]
9	Dehydrohomoplatencin		MIC against S. aureus (MSSA), 0.4 μg/mL	[19]
10	Isoplatensimycin		MIC against S. aureus (MSSA), 128 μg/mL	[20]
11	Carbaplatensimycin		MIC against S. aureus, 0.4–1.1 μg/mL	[21]
12	Platensimycin B1 and B3		Not tested	[22]
13	Platensimide A		Not tested	[22]
14	Homoplatensimide A and homoplatensimide A methyl ester		Not tested	[22]
15	Dialkylamino-2,4-dihydroxybenzoic acids analogues of Platensimycin		Out of 18 Synthesized derivatives, four derivatives which have the substitution 1, 2, 3, and 4, respectively, have shown potential activity against B. subtilis (MIC 2–8 μg/mL)	[23]
16	(−)-nor-platencin		MIC against S. aureus (MSSA), 5 μg/mL	[24]
17	Adamantaplatensimycin		MIC of (−)-adamantaplatensimycin against S. aureus (MSSA), 1.3–1.8 μg/mL; MIC of (+)-adamantaplatensimycin against S. aureus (MSSA), >88 μg/mL	[25]