Table 1.
Effect of CCBs and standard drugs on parasites and mammalian cells.
| Drug | IC50 (μM) ± SDa | |||||
|---|---|---|---|---|---|---|
|
L. (L.) infantum
promastigotes |
L. (L.) infantum
amastigotes |
L. (L.) amazonensis
promastigotes |
L. (V.) braziliensis
promastigotes |
T. cruzi
trypomastigotes |
LLC-MK2 cytotoxicity |
|
| Amrinone | neb | neb | neb | neb | neb | >500 |
| Fendiline | 16.15 ± 4.20 | 12.20 ± 1.74 | 8.66 ± 1.27 | 9.15 ± 0.78 | 12.13 ± 2.97 | 49.85 ± 8.16 |
| Lidoflazine | 17.67 ± 0.93 | 16.29 ± 4.45 | 11.54 ± 1.49 | 14.48 ± 1.08 | 10.39 ± 1.87 | 106.54 ± 57.99 |
| Mibefradil | 3.60 ± 0.11 | neb | 2.23 ± 0.42 | 2.75 ± 0.39 | 2.99 ± 0.43 | 11.96 ± 1.03 |
| Pentamidine | 1.06 ± 0.12 | ndc | 1.14 ± 0.15 | 0.69 ± 0.04 | ndc | 23.48 ± 3.53 |
| Glucantimed | ndc | 30.15 ± 1.18 | ndc | ndc | ndc | >500 |
| Benznidazole | ndc | ndc | ndc | ndc | 440.18 ± 39.14 | >500 |
aIC50: 50% inhibitory concentration ± standard deviation (SD).
bne: not effective.
cnd: not determined.
dConcentrations for Glucantime are expressed as µg/mL, as the molecular weight is unknown.