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. 2016 Feb 8;213(2):251–271. doi: 10.1084/jem.20150568

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© 2016 Lin et al.

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Figure 6. — Bhlhe40 is essential for the encephalitogenicity of Th cells in adoptive transfer models of EAE. (A) ICS plots for the indicated cytokines from polarized WT and Bhlhe40^−/− 2D2 Th1 or Th17 cells at day 4 of culture. One experiment out of three is shown (n = 10–14 mice/group). (B and C) Mean EAE scores of WT mice after receiving transfers of WT or Bhlhe40^−/− 2D2 Th1 (B) or Th17 (C) cells. Data are combined from four (Th1, n = 10–14) or two (Th17, n = 10–11) experiments. Incidence of clinical disease is indicated. (D–G) ICS plots for the indicated cytokines (D and F) and quantitation of the frequency (E and G) of cytokine-producing WT and Bhlhe40^−/− 2D2 Th1 (D and E) or Th17 (F and G) cells in the spleen and CNS on days 28–34 after immunization. (D and E) Data are combined from two independent experiments (n = 7/group). (F and G) One experiment of two is shown (n = 3–4/group). Data are mean ± SEM. Unpaired two-tailed Student's t test was performed to determine significance. **, P ≤ 0.01; ***, P ≤ 0.001.