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. 2016 Feb 8;213(2):189–207. doi: 10.1084/jem.20150894

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© 2016 Xi et al.

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Figure 5. — Soluble ST2 protects photoreceptors from phototoxic stress. (A) BALB/c mice were subretinally injected with an AAV (AAV2/5) expressing soluble ST2 (AAV-sST2) or AAV empty vector (AAV-EV) which served as a negative control. Expression of sST2 in the retina and RPE/choroid 3 wk after infection was analyzed by ELISA and Western blotting (10 µg of retina lysates and 3 µg of RPE/choroid lysates). rsST2, recombinant soluble ST2-His. (B) Mice were subretinally injected with AAV-sST2 or AAV-EV and exposed to light 3 wk after infection. Rods and cones were quantified by flow cytometry before (d0) and after 7 d CLE. Each data point represents an individual mouse (n = 10/group). ***, P < 0.001; ****, P < 0.0001; unpaired two-tailed Student’s t tests. Data are representative of two independent experiments with similar results.