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. 2016 Feb 8;213(2):235–249. doi: 10.1084/jem.20150990

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© 2016 Cho et al.

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Figure 7. — Deletion of both miR-23 clusters in T cells resulted in increased Th2 differentiation and IL-4 expression. (A) Clustering of RNA-seq results from T-DKO, R23CTg, and WT naive CD4⁺ T cells based on total gene expression. FACS analysis (B), frequencies (C), and MFI of IL-4 in CD4⁺ T cells isolated from T-DKO mice or WT littermates cultured under Th2-polarizing conditions. (D) FACS analysis and MFI of GATA3 from T-DKO CD4⁺ T cells compared with WT CD4⁺ T cells. qPCR analysis of IL-4 and GATA3 expression in T cells isolated from T-DKO mice (E) and R24Tg or R27Tg mice (F) upon Th2 polarization. All data are representative of two independent experiments. n = 3–6. *, P < 0.05; **, P < 0.01; ***, P < 0.001.