Figure 1. Association between maternal plasma folate and DNA methylation in newborn cord blood: meta-analysis results for MoBa (N=1,275) and Generation R (N=713) cohorts.

The uncorrected –log10(P values) are plotted by CpG genomic position. Multiple testing was accounted for using the false discovery rate (FDR) procedure by Benjamini and Hochberg. A total of 443 CpGs were considered FDR significant (solid horizontal line); 48 CpGs were also Bonferroni significant (dashed horizontal line).