Table 1. The variability of coefficients for each reaction moiety over time after exposure of Zs + cells (cancer stem calls) and Zs− cells (non cancer stem cells) to anti-tumour agents.
| Time point (h) | ||||
|---|---|---|---|---|
| 0 | 24 | 72 | CV error | |
| Reaction moiety | ||||
| Putrescine | ||||
| Zs+ | ||||
| ODC1 | 3.93E-04 | −5.87E−05 | 4.53E-05 | |
| SRM | −4.33E−04 | −8.29E−04 | −1.16E−04 | 1.67E-09 |
| SAT1 | −6.59E−06 | 1.16E-05 | 1.24E-04 | |
| Zs− | ||||
| ODC1 | 1.00E-05 | 1.89E-04 | 3.07E-04 | |
| SRM | −3.22E−05 | −4.02E−04 | −6.73E−04 | 3.78E-11 |
| SAT1 | 1.56E-04 | 5.47E-05 | 2.35E-05 | |
| Spermidine | ||||
| Zs+ | ||||
| SRM | 1.69E-06 | −4.44E−05 | 1.53E-05 | |
| SAT2 | 1.15E-05 | −1.12E−04 | 3.67E-07 | 8.84E-13 |
| SAT1 | −3.23E−04 | −2.25E−04 | −1.37E−04 | |
| SMS | −4.51E−05 | −1.16E−04 | −8.62E−06 | |
| Zs− | ||||
| SRM | 6.12E-05 | 2.48E-06 | 1.15E-05 | 1.67E-12 |
| SAT2 | −1.03E−05 | 1.97E-03 | 1.12E-06 | |
| SAT1 | −3.39E−04 | −1.27E−04 | −1.33E−04 | |
| SMS | −5.85E−05 | −7.35E−04 | −7.76E−06 | |
| Spermine | ||||
| Zs+ | ||||
| SMS | 1.95E-09 | 1.07E-05 | 9.49E-05 | 8.03E-15 |
| SAT2 | −6.13E−03 | −4.50E−03 | −5.04E−04 | |
| Zs− | ||||
| SMS | 5.13E-09 | 7.63E-05 | 6.43E-10 | 2.79E-15 |
| SAT2 | −4.85E−03 | −4.57E−03 | −3.95E−03 | |
CV errors are shown for each cell.
CV, cross-validation; ODC, ornithine decarboxylase; SAT2, spermine N1-acetyltransferase 2; SMS, spermine synthase.