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. 2016 Feb 10;7:10619. doi: 10.1038/ncomms10619

Figure 1. Design and characterization of DNA nanocage-encapsulated enzymes with controlled stoichiometry.

Figure 1

(a) Schematic representations of the assembly of a DNA nanocage encapsulating a pair of GOx (orange) and HRP (green) enzymes. Individual enzymes were first attached to half-cages, followed by the addition of linker strands (red) to combine the two halves into a full-cage. Small pores of honeycomb shape (∼2.5 nm d.i.) were designed on the bottom of cages to facilitate the diffusion of substrate molecules in an out of the cage. (b) Negatively stained TEM images of DNA cages containing a single GOx (shown as less stained dots) and (c) a pair of GOx and HRP (shown as less stained dots). Scale bar, 50 nm.