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. 2016 Feb 11;6:21658. doi: 10.1038/srep21658

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Copyright © 2016, Macmillan Publishers Limited

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(a) N2a and 22LN2a cells were treated for 10 days with glivec (+ Gli; 10 μM) or not (−Gli). Cells were lysed and lysates were subjected to PK digestion (+PK; 20 μg/ml) or not (−PK). Aliquots were analysed by immunoblot using anti-PrP mAb 4H11. (b) Crude membrane extracts (100 μg protein) of N2a or 22LN2a cells treated with glivec (+Gli) or not (−Gli) were subjected to immunoblot and analysed for rab7, rab9 or rab11 levels. TRAPα served as a loading control. Signals of three (+Gli) or six (−Gli) independent experiments were densitometrically quantified and statistically evaluated using one-way ANOVA and Tukey’s test (GraphPad Prism; *p-value < 0.05; ns = not significant). Bars represent standard deviation.