Figure 7. PrP^Sc accumulation reduces rab7 membrane attachment and lysosomal maturation.

In prion infected neuronal cells, PrP^Sc accumulates at the plasma membrane and along the endocytic pathway (1). This results in an impairment of rab7 attachment to membranes (2). As a consequence, lysosomal maturation and overall degradation capacity are impaired (3).