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. 2016 Feb 11;6:20903. doi: 10.1038/srep20903

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Copyright © 2016, Macmillan Publishers Limited

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(a) TEM photograph shows characteristics of the marginal cell. Arrows indicate lysosomes (LS), mitochondria (MC), coated vesicles (CV), uncoated vesicles (UV), small invaginations (MI), microvilli-like extensions (MV), lamellar bodies (LB), respectively. Scale bars, 1 μm. (b) Marginal cells under TEM. Arrows indicate LS, MV and LB, respectively. Scale bars, 2 μm. (c,d) TEMs of marginal cells loaded with quinacrine for 30 min. Arrows indicate quinacrine labeled lysosomes and unlabeled mitochondria. Neighboring cells were connected with tight junctions. Scale bars, 2 μm. (e,f) Lysosomal exocytosis was observed in marginal cells that contained granules stained with quinacrine. TEM showed the characteristics of the marginal cells and lysosomal exocytosis. A coated omega-shaped invagination was found in the apical plasma membrane of the marginal cells (e). Scale bars, 5 μm.