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. 2016 Feb 11;6:20989. doi: 10.1038/srep20989

Figure 1. Thrombin-induced barrier disruption in PAECs.

Figure 1

(a) A representative trace of the changes in the TEER induced by 1 u ml−1 thrombin. (b) The concentration-dependent effects of thrombin on the TEER at 3 min after stimulation (n = 3–7). (c) A summary of the temporal changes in the TEER induced by 1 u ml−1 thrombin without (Thrombin; n = 12) and with 1 μM E5555 (Thrombin + E5555; n = 4), 30 μM PAR1-AP (n = 4) and 30 μM PAR4-AP (n = 6). The data are the means ± SEM. *P < 0.05 vs. thrombin, according to an ANOVA followed by Dunnett’s post-hoc test.