. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: Mol Aspects Med. 2016 Jan 14;0:76–89. doi: 10.1016/j.mam.2016.01.002

TABLE 1.

O₂-dependent ROS regulation of Kv and L-type Ca²⁺ channel activity in the regulation of tone in PASMC, Ductus Arteriosus and SASMC, as proposed by Archer, Weir, Michelakis and coworkers.

PASMC		Ductus Arteriosus		SASMC
Hypoxia	High PO₂	Hypoxia	High PO₂	Hypoxia	High PO₂

ROS Decrease	ROS Increase	ROS Decrease	ROS Increase	ROS Increase	ROS Decrease

Kv Closure	Kv Open	Kv Open	Kv Closure	Kv Open	Kv Closure

L-type Open	L-type Closure	L-type Closure	L-type Open	L-type Closure	L-type Open

Constriction	Relaxation	Relaxation	Constriction	Relaxation	Constriction

See text for explanation of these responses.