Table 1.

Clinical pathological features of the 59 GIST cases according to DOG1 expression

Patient characteristics	Cumulative population	DOG1
		Positive	Negative
Sex
Male, n (%)	31 (52.5 %)	19 (48.7 %)	12 (60 %)	p = 0.413
Female, n (%)	28 (47.5 %)	20 (51.3 %)	8 (40 %)
Age (years)
Mean (±SD)	63.3 (±14.6)	63.1 (±16.9)	63.6 (±12.8)	p = 0.8973
Median	67	65	66.5
Range	28–88	28–88	34–82
Primary site				p = 0.0652
Stomach	39 (66.1 %)	29 (74.3 %)	10 (50 %)
Small intestine	12 (20.3 %)	8 (20.5 %)	4 (20 %)
Large bowel	4 (6.8 %)	1 (2.6 %)	3 (15 %)
Others	4 (6.8 %)	1 (2.6 %)	3 (15 %)
Tumor size (cm)				p = 0.0002
Mean (±SD)	8.3 (±5.5)	10.1 (±5.8)	4.7 (±1.9)
Median	6	8	4.7
Range	2–20	3–20	2–10
Histological subtype				p = 0.2
Spindle type	45 (76.3 %)	27 (69.2 %)	18 (90 %)
Epithelial type	6 (10.2 %)	5 (12.8 %)	1 (5 %)
Mixed type	8 (13.5 %)	7 (18 %)	1 (5 %)
Mitoses per 50 HPFs
≤ 5	25 (42.4 %)	15 (38.5 %)	10 (50 %)	p = 0.54
6–10	17 (28.8 %)	13 (33.3 %)	4 (20 %)
≥ 10	17 (28.8 %)	11 (28.2 %)	6 (30 %)
Mutated exon
KIT exon 11	30 (56.6 %)	24 (68.6 %)	6 (33.5 %)	p = 1
KIT exon 9	2 (3.8 %)	2 (5.7 %)	0
KIT exon 13	2 (3.8 %)	2 (5.7 %)	0
KIT exon 17	1 (1.9 %)	0	1 (5.5 %)
PDGFRA exon 12	1 (1.9 %)	0	1 (5.5 %)	p = 0.889
PDGFRA exon 18	3 (5.6 %)	2 (5.7 %)	1 (5.5 %)
Wild type	14 (26.4 %)	5 (14.3 %)	9 (50 %)	p = 0.009
Not available	6	4	2

HPF high power field of the microscope; p-values computed using Fisher exact test or χ ² test