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. 1995 Oct;50(10):1087–1092. doi: 10.1136/thx.50.10.1087

Relationship between cells obtained by bronchoalveolar lavage and survival in idiopathic pulmonary fibrosis.

K A Boomars 1, S S Wagenaar 1, P G Mulder 1, H van Velzen-Blad 1, J M van den Bosch 1
PMCID: PMC475023  PMID: 7491558

Abstract

BACKGROUND--The relationship between cell types in bronchoalveolar lavage (BAL) fluid and the clinical course of patients with idiopathic pulmonary fibrosis (IPF) has been the subject of several studies. However, the results of these studies are not conclusive. The aim of this study was to investigate the relationship between the absolute and relative cell numbers in BAL fluid from patients with IPF and their survival. METHODS--Results obtained from the initial BAL fluid analyses of all histologically proven cases of IPF (n = 49) were selected retrospectively. Cox's proportional hazards survival analysis was used for estimating the relationship between absolute and relative cell numbers and survival. RESULTS--A negative relationship was found between both the absolute numbers and percentages of eosinophils in BAL fluid samples and survival. No such relationship was demonstrated for the absolute numbers or the percentages of any other cell type. CONCLUSIONS--Although this study has restrictions, these findings suggest a negative relationship between the absolute numbers and percentages of eosinophils in BAL fluid samples and survival in patients with IPF.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agius R. M., Godfrey R. C., Holgate S. T. Mast cell and histamine content of human bronchoalveolar lavage fluid. Thorax. 1985 Oct;40(10):760–767. doi: 10.1136/thx.40.10.760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aldenborg F., Nilsson K., Jarlshammar B., Bjermer L., Enerbäck L. Mast cells and biogenic amines in radiation-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 1993 Jan;8(1):112–117. doi: 10.1165/ajrcmb/8.1.112. [DOI] [PubMed] [Google Scholar]
  3. Davis W. B., Fells G. A., Sun X. H., Gadek J. E., Venet A., Crystal R. G. Eosinophil-mediated injury to lung parenchymal cells and interstitial matrix. A possible role for eosinophils in chronic inflammatory disorders of the lower respiratory tract. J Clin Invest. 1984 Jul;74(1):269–278. doi: 10.1172/JCI111411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Drent M., Mulder P. G., Wagenaar S. S., Hoogsteden H. C., van Velzen-Blad H., van den Bosch J. M. Differences in BAL fluid variables in interstitial lung diseases evaluated by discriminant analysis. Eur Respir J. 1993 Jun;6(6):803–810. [PubMed] [Google Scholar]
  5. Haslam P. L., Cromwell O., Dewar A., Turner-Warwick M. Evidence of increased histamine levels of lung lavage fluids from patients with cryptogenic fibrosing alveolitis. Clin Exp Immunol. 1981 Jun;44(3):587–593. [PMC free article] [PubMed] [Google Scholar]
  6. Haslam P. L., Dewar A., Butchers P., Primett Z. S., Newman-Taylor A., Turner-Warwick M. Mast cells, atypical lymphocytes, and neutrophils in bronchoalveolar lavage in extrinsic allergic alveolitis. Comparison with other interstitial lung diseases. Am Rev Respir Dis. 1987 Jan;135(1):35–47. doi: 10.1164/arrd.1987.135.1.35. [DOI] [PubMed] [Google Scholar]
  7. Haslam P. L., Turton C. W., Lukoszek A., Salsbury A. J., Dewar A., Collins J. V., Turner-Warwick M. Bronchoalveolar lavage fluid cell counts in cryptogenic fibrosing alveolitis and their relation to therapy. Thorax. 1980 May;35(5):328–339. doi: 10.1136/thx.35.5.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Heard B. E., Dewar A., Corrin B. Apposition of fibroblasts to mast cells and lymphocytes in normal human lung and in cryptogenic fibrosing alveolitis. Ultrastructure and cell perimeter measurements. J Pathol. 1992 Mar;166(3):303–310. doi: 10.1002/path.1711660314. [DOI] [PubMed] [Google Scholar]
  9. Kawanami O., Ferrans V. J., Fulmer J. D., Crystal R. G. Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders. Lab Invest. 1979 Jun;40(6):717–734. [PubMed] [Google Scholar]
  10. Kroegel C., Matthys H., Costabel U. Morphology and density features of eosinophil leukocytes in eosinophilic pneumonia. A case report. Clin Investig. 1992 May;70(5):447–453. doi: 10.1007/BF00235531. [DOI] [PubMed] [Google Scholar]
  11. Libby D. M. The eosinophil in idiopathic pulmonary fibrosis. Chest. 1987 Jul;92(1):7–8. doi: 10.1378/chest.92.1.7. [DOI] [PubMed] [Google Scholar]
  12. Mori H., Kawada K., Zhang P., Uesugi Y., Sakamoto O., Koda A. Bleomycin-induced pulmonary fibrosis in genetically mast cell-deficient WBB6F1-W/Wv mice and mechanism of the suppressive effect of tranilast, an antiallergic drug inhibiting mediator release from mast cells, on fibrosis. Int Arch Allergy Appl Immunol. 1991;95(2-3):195–201. doi: 10.1159/000235429. [DOI] [PubMed] [Google Scholar]
  13. Pesci A., Bertorelli G., Gabrielli M., Olivieri D. Mast cells in fibrotic lung disorders. Chest. 1993 Apr;103(4):989–996. doi: 10.1378/chest.103.4.989. [DOI] [PubMed] [Google Scholar]
  14. Peterson M. W., Monick M., Hunninghake G. W. Prognostic role of eosinophils in pulmonary fibrosis. Chest. 1987 Jul;92(1):51–56. doi: 10.1378/chest.92.1.51. [DOI] [PubMed] [Google Scholar]
  15. Pincus S. H., Ramesh K. S., Wyler D. J. Eosinophils stimulate fibroblast DNA synthesis. Blood. 1987 Aug;70(2):572–574. [PubMed] [Google Scholar]
  16. Rankin J. A., Kaliner M., Reynolds H. Y. Histamine levels in bronchoalveolar lavage from patients with asthma, sarcoidosis, and idiopathic pulmonary fibrosis. J Allergy Clin Immunol. 1987 Feb;79(2):371–377. doi: 10.1016/0091-6749(87)90158-8. [DOI] [PubMed] [Google Scholar]
  17. Schwartz D. A., Helmers R. A., Galvin J. R., Van Fossen D. S., Frees K. L., Dayton C. S., Burmeister L. F., Hunninghake G. W. Determinants of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):450–454. doi: 10.1164/ajrccm.149.2.8306044. [DOI] [PubMed] [Google Scholar]
  18. Tomioka M., Goto T., Lee T. D., Bienenstock J., Befus A. D. Isolation and characterization of lung mast cells from rats with bleomycin-induced pulmonary fibrosis. Immunology. 1989 Mar;66(3):439–444. [PMC free article] [PubMed] [Google Scholar]
  19. Turner-Warwick M., Burrows B., Johnson A. Cryptogenic fibrosing alveolitis: clinical features and their influence on survival. Thorax. 1980 Mar;35(3):171–180. doi: 10.1136/thx.35.3.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Turner-Warwick M., Haslam P. L. The value of serial bronchoalveolar lavages in assessing the clinical progress of patients with cryptogenic fibrosing alveolitis. Am Rev Respir Dis. 1987 Jan;135(1):26–34. doi: 10.1164/arrd.1987.135.1.26. [DOI] [PubMed] [Google Scholar]
  21. Venge P., Dahl R., Fredens K., Peterson C. G. Epithelial injury by human eosinophils. Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S54–S57. doi: 10.1164/ajrccm/138.6_Pt_2.S54. [DOI] [PubMed] [Google Scholar]
  22. Venge P. What is the role of the eosinophil? Thorax. 1990 Mar;45(3):161–163. doi: 10.1136/thx.45.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Walls A. F., Bennett A. R., Godfrey R. C., Holgate S. T., Church M. K. Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease. Clin Sci (Lond) 1991 Aug;81(2):183–188. doi: 10.1042/cs0810183. [DOI] [PubMed] [Google Scholar]
  24. Watters L. C., Schwarz M. I., Cherniack R. M., Waldron J. A., Dunn T. L., Stanford R. E., King T. E. Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy. Am Rev Respir Dis. 1987 Mar;135(3):696–704. doi: 10.1164/arrd.1987.135.3.696. [DOI] [PubMed] [Google Scholar]
  25. Wells A. U., Cullinan P., Hansell D. M., Rubens M. B., Black C. M., Newman-Taylor A. J., Du Bois R. M. Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. Am J Respir Crit Care Med. 1994 Jun;149(6):1583–1590. doi: 10.1164/ajrccm.149.6.8004317. [DOI] [PubMed] [Google Scholar]
  26. Wells A. U., Hansell D. M., Rubens M. B., Cullinan P., Haslam P. L., Black C. M., Du Bois R. M. Fibrosing alveolitis in systemic sclerosis. Bronchoalveolar lavage findings in relation to computed tomographic appearance. Am J Respir Crit Care Med. 1994 Aug;150(2):462–468. doi: 10.1164/ajrccm.150.2.8049830. [DOI] [PubMed] [Google Scholar]
  27. de Cremoux H., Bernaudin J. F., Laurent P., Brochard P., Bignon J. Interactions between cigarette smoking and the natural history of idiopathic pulmonary fibrosis. Chest. 1990 Jul;98(1):71–76. doi: 10.1378/chest.98.1.71. [DOI] [PubMed] [Google Scholar]

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