Table 2.
Epidemiological parameters considered in the analytic models. Brazilian Amazon, 2013
| Parameter | Base-case | Variations | Sources base-case/variations |
|---|---|---|---|
| Proportion of malaria among febrile males seeking diagnosisa | 0.0886 | 0.0881–0.0891 | [4] /IC 95 % |
| Proportion of malaria cases due to P. vivax in male patientsa | 0.835 | 0.833–0.837 | [4] /IC 95 % |
| Prevalence of G6PDd in male patients | 0.045 | 0.025–0.056 | [7] /f]–[7] IC 95 % |
| Proportion of males with G6PDd hospitalized after treatment with PQb | 0.943 | 0.744–1 | [39] /± 20 % |
| Proportion of the use of BX-G6PDc | 0.184 | 0.182–0.187 | [4, 21] /IC 95 % |
| Sensitivity of CS-G6PDd | 0.455 | 0.213–0.720 | f/IC 95 % |
| Specificity of CS-G6PDd | 0.987 | 0.967–0.995 | f/IC 95 % |
| Sensitivity of BX-G6PDd, e | 0.667 | 0.301–0.921 | [16] /IC 95 % |
| Specificity of BX-G6PDd, e | 1 | 0.989–1 | [16] /IC 95 % |
aParameter obtained from the analysis of the databanks from the nine States of the Brazilian Amazon
bParameter obtained from follow-up of patients with G6PDd in FMT-HVD
cProportion corresponding to individuals diagnosed with P. vivax malaria, residents of municipalities with more than 100,000 inhabitants
dThe cutoff point: 40 % of the median enzyme activity in the sample
eThe base-case and the variation considering data from Brazil and Peru
fBrito et al. Personal Communication, 2015