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Mouse macrophages expressing both CCR2 and Fpr2 infiltrate transplanted LLC where macrophages undergo M1 polarization in response to tumor-derived Fpr2 ligands. Macrophages-deficient in Fpr2 express high levels of CCR4, which synergizes with CCR2 to recruit TAM in response to tumor-derived CCL2, followed by polarization into M2 cells in response to an as-yet-undefined tumor microenvironment factor.
