Table 1.
Enzyme | Class/Function |
---|---|
• APE1 | Incises at abasic sites |
• EXOG & DNA2 | exonucleases that remove flaps |
• Pol γ | dRP lyase and gap filling |
• DUT1 | hydrolyses dUTP to dUDP1 |
• ENDOG | endonuclease2 |
• Lig3 | ligates repair patches or DS breaks |
• MGMT: O6-methylguanine DNA methyltransferase | removes methyl group from O6-methylguanine |
• MTH1, MutT homolog | hydrolyzes 8-oxodGTP to 8-oxodGMP1 |
• MYH, MutY homolog | removes A from 8-oxodG/A pairs |
• NEIL2, endonuclease VIII homolog | glycosylase/AP lyase removes oxidized bases |
• NTH1, endonuclease III homolog | glycosylase/AP lyase removes oxidized pyrimidines |
• OGG-1 | glycosylase/AP lyase removes 8-oxo-guanine from oxo-G/C pairs |
• SSB | single-strand binding protein2 |
• TFAM | transcription factor A, member of the HMG family, binds DS DNA2 |
• UNG, uracil gly | glycosylase, removes uracil |
removes damaged nucleotide triphosphate from dNTP pool protecting misincorporation during DNA replication
direct role in DNA repair has not been shown