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Knockdown of endogenous progranulin (PGRN) aggravated neurologic deficits after subarachnoid hemorrhage (SAH). A, PGRN expression decreased at 24 hr after SAH and continued to decrease after PGRN siRNA administration. B, Knockdown of endogenous PGRN significantly aggravated neurologic deficits at 24 hr after SAH. n = 6 for each group. *p < 0.05 versus sham; #p < 0.05 versus SAH + scramble siRNA.
