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UPR blocks the nuclear translocation of DNase IIβ in lens fiber cells. P1 lenses from WT (A) and mutant Col IV transgenic mice (B) were cryosectioned and immunostained with anti- DNAse IIβ (red) and counterstained with DAPI (blue). Lysosomes are stained with anti-Lamp1 (green). Right: higher magnification of boxed areas. Scale bars, 50 μm.
