Metabolic profiles in 20-wk-old WT, NOD, SCID, and NSG mice fed a standard chow diet (n = 5–11 mice per group, left) or after 6 wk of an HFD (n = 6–15 mice per group, right). A) Body weights. B, C) Whole-body lean mass (B) and fat mass (C) measured using 1H-MRS. *P < 0.05 vs. WT mice fed a respective diet.