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Insulin-stimulated whole-body glucose turnover (A), glycolysis (B), and glycogen synthesis (C) during a 2 h hyperinsulinemic-euglycemic clamp in 20-wk-old WT, NOD, SCID, and NSG mice fed a standard chow diet (n = 5–11 mice per group, left) or after 6 wk of an HFD (n = 6–15 mice per group, right). *P < 0.05 vs. WT mice fed a respective diet.
