Figure 4.

Insulin-stimulated glucose uptake in individual organs was measured using a bolus injection of 2-[¹⁴C]DG during hyperinsulinemic-euglycemic clamp in 20-wk-old WT, NOD, SCID, and NSG mice fed a standard chow diet (n = 5–11 mice per group, left) or after 6 wk of an HFD (n = 6–15 mice per group, right). A) Skeletal muscle glucose uptake (gastrocnemius). B) Glucose uptake in epidydimal white adipose tissue (WAT). C) Glucose uptake in intrascapular brown adipose tissue (BAT). D) Myocardial glucose uptake. *P < 0.05 vs. WT mice fed a respective diet.