TABLE 1.

Metabolic parameters at basal state and during hyperinsulinemic-euglycemic clamp in conscious mice

		Basal state		Clamp period
Diet and genotype	Number	Plasma glucose (mM)	Plasma insulin (pM)	Plasma glucose (mM)	Plasma insulin (pM)
Chow
WT	6	8.2 ± 0.3	ND	7.4 ± 0.4	ND
NOD	5	5.9 ± 0.2*	64 ± 5	7.0 ± 0.4	168 ± 7
SCID	11	5.0 ± 0.2*	89 ± 15	6.7 ± 0.2	215 ± 27
NSG	6	5.2 ± 0.4*	73 ± 2	7.0 ± 0.4	164 ± 10
HFD
WT	6	10.8 ± 0.7	ND	6.4 ± 0.5	ND
NOD	6	6.4 ± 0.8*	103 ± 17	6.4 ± 0.3	240 ± 22
SCID	15	5.2 ± 0.2*	109 ± 9	7.2 ± 0.4	255 ± 15
NSG	8	5.3 ± 0.4*	79 ± 2	7.3 ± 0.4	197 ± 11

ND, not determined. *P < 0.05 vs. WT.