. 2016 Feb 11;21(2):026006. doi: 10.1117/1.JBO.21.2.026006

Table 1.

Experimental design: animal groups, pretreatment and imaging approaches.

Animal groups			Pretreatment	Drug challenge during experiment	Imaging approach
Group 1	A Control ( $n = 6$ )	$A_{0}$ 2-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ , i.p.)	N/A	In vivo (3-D OCT)
	A Control ( $n = 6$ )	$A_{1}$ 4-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ , i.p.)
	B Cocaine (2 weeks, $n = 5$ )		Cocaine (2 weeks) ( $35 mg / kg / day$ , i.p.)
	C Cocaine (4 weeks, $n = 5$ )		Cocaine (4 weeks) ( $35 mg / kg / day$ , i.p.)
Group 2	A Control ( $n = 8$ )	$A_{0}$ 2-week control ( $n = 4$ )	0.9% saline ( $0.7 cc / 100 g / day$ i.p.)	N/A	Ex vivo(fluorescein isothiocyanate-Dextran)
	A Control ( $n = 8$ )	$A_{1}$ 4-week control ( $n = 4$ )	0.9% saline ( $0.7 cc / 100 g / day$ i.p.)
	B Cocaine (2 weeks, $n = 6$ )		Cocaine (2 weeks) ( $35 mg / kg / day$ , i.p.)
	C Cocaine(4 weeks, $n = 6$ )		Cocaine (4 weeks) ( $35 mg / kg / day$ , i.p.)
Group 3	A Control ( $n = 6$ )	$A_{0}$ 2-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ i.p.)	N/A	Ex vivo (VEGF)
	A Control ( $n = 6$ )	$A_{1}$ 4-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ i.p.)
	B Cocaine (2 weeks, $n = 4$ )		Cocaine (2 weeks) ( $35 mg / kg / day$ , i.p.)
	C Cocaine (4 weeks, $n = 4$ )		Cocaine (2 weeks) ( $35 mg / kg / day$ , i.p.)
Group 4	A Control ( $n = 6$ )	$A_{0}$ 2-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ , i.p.)	0.9% saline ( $0.1 cc / 100 g$ , i.v.)	In vivo (MW-LSI)
	A Control ( $n = 6$ )	$A_{1}$ 4-week control ( $n = 3$ )	0.9% saline ( $0.7 cc / 100 g / day$ , i.p.)	0.9% saline ( $0.1 cc / 100 g$ , i.v.)
	B Cocaine (2 weeks, $n = 3$ )		Cocaine (2 weeks) ( $35 mg / kg / day$ , i.p.)	Cocaine ( $1 mg / kg$ , i.v.)
	C Cocaine(4 weeks, $n = 3$ )		Cocaine (4 weeks) ( $35 mg / kg / day$ , i.p.)	Cocaine ( $1 mg / kg$ , i.v.)