Table 5.
Fold differences of the affected most influential component when the upstream component was perturbed.
| Perturbed component | Affected component | Fold differences (perturbed/WT) |
|||
|---|---|---|---|---|---|
| Death | Growth | Motility | Quiescence | ||
| IP3R1 (inactivation) | PI3K | 2.38-Folda | 1.03-Fold | 1.04-Fold | 1.14-Fold |
| PI3K (inactivation) | IP3R1 | 5.42-Folda | 1.18-Fold | 1.15-Fold | 1.24-Fold |
| IP3R1 (inactivation) | RGS | NSA | Complete inactivation | Complete inactivation | Complete inactivation |
| RGS (inactivation) | IP3R1 | NSA | 1.21-Fold | 1.18-Fold | 1.24-Fold |
| Gbg_i (inactivation) | CaM | NSA | NSA | Complete inactivation | Complete inactivation |
| CaM (inactivation) | Gbg_i | NSA | NSA | 1.30-Fold | 1.43-Fold |
| Grb2 (activation) | Ras | 7.40-Folda | 1.32-Fold | 1.39-Fold | 2.13-Fold |
| Ras (activation) | Grb2 | 0.99-Fold | 0.97-Fold | 0.99-Fold | 1.01-Fold |
| Grb2 (activation) | Sos | 7.87-Folda | 1.39-Fold | 1.53-Fold | 2.18-Fold |
| Sos (activation) | Grb2 | 1-Fold | 0.97-Fold | 0.99-Fold | 1.01-Fold |
| Rac (activation) | PAK | 18.41-Folda | 5.69-Fold | NSA | NSA |
| PAK (activation) | Rac | 1.18-Fold | 1.24-Fold | NSA | NSA |
NSA, not significantly affected (KST value <1).
aTwofold or above change.