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. 2016 Feb 10;3:15056. doi: 10.1038/mtm.2015.56

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effect of radiation-based immune suppression following AAV-FVIII gene therapy. (a) Anti-ET3 IgG titers were measured by ELISA in naive hemophilia A mice preimmunized with ET3 and then treated with 4 × 10¹² vp/kg AAV8-HLP-ET3 vector posttransplant. Mice were conditioned with 11 Gy total body irradiation and then transplanted with 5 million whole bone marrow cells (n = 4). (b) Individual anti-ET3 IgG titers measured by ELISA. AAV, adeno-associated virus; HLP, hybrid liver-specific promoter.