Table 1.

Association Between Glioma Risk and Selected SNPS (rs78378222 and rs35850753) for Glioma Overall, and Stratified by Study Design, Tumor Type, Age of Onset, and Family History of Brain Tumor

Locus (reference allele, effect allele)	Chr	Pos (hg19)	Model	Effect allele frequency in cases	Effect allele frequency in controls	Cases	Controls	P value	OR	(95% CI)	Heterogeneity P valuea
rs78378222 (A,C)	17	7,571,752	Overall	0.0292	0.0125	1,856	4,955	6.48 × 10−11	3.14	(2.23–4.43)
			Case-control	0.0302	0.0122	1,300	2,014	3.06 × 10−8	3.31	(2.17–5.06)	0.92
			Cohort	0.0274	0.0128	543	2,939	1.59 × 10−4	3.19	(1.75–5.83)
			GBM	0.0314	0.0125	970	4,955	6.75 × 10−10	4.17	(2.65–6.56)	0.24
			Non-GBM	0.0268	0.0125	885	4,955	9.06 × 10−7	3.56	(2.15–5.92)
			Early onset	0.0299	0.0125	502	4,955	1.46 × 10−6	4.45	(2.42–8.17)	0.99
			Late onset	0.029	0.0125	1,353	4,955	3.72 × 10−10	3.23	(2.24–4.67)
			FH positive	0.0364	0.0086	105	59	1.13 × 10−1	3.31	(0.75–14.53)	0.39
			FH negative	0.0273	0.0115	1,384	2,220	1.19 × 10−7	2.82	(1.92–4.14)
rs35850753 (G,A)	17	7,578,671	Overall	0.0403	0.0243	1,856	4,955	2.68 × 10−6	1.88	(1.45–2.45)
			Case-control	0.0406	0.0232	1,299	2,015	3.52 × 10−5	2.02	(1.45–2.82)	0.63
			Cohort	0.0404	0.0251	543	2,939	1.43 × 10−2	1.76	(1.12–2.75)
			GBM	0.0441	0.0243	970	4,954	2.85 × 10−6	2.24	(1.60–3.13)	0.17
			Non-GBM	0.0361	0.0243	885	4,954	1.15 × 10−2	1.61	(1.11–2.32)
			Early onset	0.0396	0.0243	502	4,954	1.28 × 10−3	2.05	(1.32–3.18)	0.85
			Late onset	0.0405	0.0243	1,352	4,954	6.16 × 10−7	2.03	(1.54–2.68)
			FH positive	0.0472	0.009	104	59	5.64 × 10−2	3.53	(0.97–12.87)	0.47
			FH negative	0.0378	0.0217	1,385	2,220	3.23 × 10−5	1.88	(1.39–2.53)

^aHeterogeneity P value is trend effect test based on case–case comparison between each pair of groups.