Table 3.
The SLC22 transporter genes
| Gene name | Common name(s) | Tissue distribution | Examples of interacting compounds |
|---|---|---|---|
| SLC22A1 | OCT1 | Liver, small intestine | Cationic drugs, polyamines |
|
| |||
| SLC22A2 | OCT2 | Kidney, small intestine |
Cationic drugs, acetylcholine, dopamine |
|
| |||
| SLC22A3 | OCT3 | Heart, skeletal muscle, CNS |
Cationic drugs, epinephrine |
|
| |||
| SLC22A4 | OCTN1 | Kidney, intestine | Carnitine, acetylcholine |
|
| |||
| SLC22A5 | OCTN2 | Skeletal muscle, kidney |
Carnitine, choline |
|
| |||
| SLC22A6 | OAT1 | Kidney, choroid plexus |
Anionic drugs, α-ketoglutarate, indoxyl sulphate |
|
| |||
| SLC22A7 | OAT2 | Liver, kidney | Anionic drugs, cyclic GMP |
|
| |||
| SLC22A8 | OAT3 | Kidney, choroid plexus, testes |
Anionic drugs, oestrone sulphate, flavonoids |
|
| |||
| SLC22A9 | OAT7 | Liver | Oestrone sulphate |
|
| |||
| SLC22A10 | – | Liver | – |
|
| |||
| SLC22A11 | OAT4 | Placenta, kidney | Urate, oestrone sulphate |
|
| |||
| SLC22A12 | URAT1 and RST | Kidney | Urate |
|
| |||
| SLC22A13 | OAT10 | Kidney, brain, colon | Organic anions, urate |
|
| |||
| SLC22A14 | OCTL2 | Kidney, colon | – |
|
| |||
| SLC22A15 | FLIPT1 | Kidney, brain, liver | – |
|
| |||
| SLC22A16 | FLIPT2, CT2 and OCT6 | Testes | Carnitine |
|
| |||
| SLC22A17 | BOIT and BOCT1 | Brain, choroid plexus | – |
|
| |||
| SLC22A18 | BWR1A and IMPT1 | Kidney | – |
|
| |||
| Slc22a19 | Oat5 | – | Oestrone sulphate |
|
| |||
| SLC22A20 | OAT6 | Olfactory | Odorants |
|
| |||
| Slc22a21 | Octn3 | – | – |
|
| |||
| Slc22a22 | Oatpg | – | Prostaglandins |
|
| |||
| SLC22A23 | – | Brain, liver | – |
|
| |||
| SLC22A24 | – | – | – |
|
| |||
| SLC22A25 | UST6 | Liver | – |
|
| |||
| SLC22A31 | – | Larynx, prostate | – |