Table 4.
Selected metabolic alterations in knockout or transgenic rodents
| Gene name (alternative name) | Metabolites (alternative name) | Refs |
|---|---|---|
| Slc22a6 (Oat1) | 3-Hydroxybutyrate | 38 |
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| Benzoate | 38 | |
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| 2-Hydroxy-3-methylvalerate | 38 | |
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| 2-Oxoglutarate (α-ketoglutarate) | 38 | |
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| Indoxyl sulphate | 61 | |
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| Indole lactic acid | 61 | |
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| Kynurenine | 61 | |
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| Pantothenic acid | 61 | |
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| Urate | 61 | |
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| Thymidine | 61 | |
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| Orotic acid | 61 | |
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| Amino-cresol sulphate | 61 | |
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| Slc22a8 (Oat3) | Pongamoside A | 159 |
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| 9-Amino-nonanoic acid | 159 | |
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| Flavin mononucleotide | 68 | |
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| Thymidine | 68 | |
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| Urate | 91 | |
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| Slco1a1 (Oatp1a1) | Trimethylamine | 162 |
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| Gulonate | 162 | |
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| Isethionic acid | 162 | |
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| Slco1a4 (Oatp1a4) | Trimethylamine | 162 |
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| Isethionic acid | 162 | |
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| SLCO4C1 (OATP4C1)* | Asymmetric dimethylarginine | 163 |
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| Guanidinosuccinic acid | 163 | |
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| Trans-aconitate | 163 | |
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| Abcc3 (Mrp3) | Enterodiol–glucuronide | 168 |
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| Secoisolariciresinol–glucuronide | 168 | |
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| Enterolactone–glucuronide | 168 | |
*
Human transporter gene transgenically overexpressed in the rat kidney.